Bioassay

oaPHARMACOLOGY dominions and Methods of assay Prof. Ramesh K. Goyal L. M. College of Pharmacy Navrangpura Ahmedabad- 380 009 (18.01.2008) CONTENTS splendour of Bioassay Principle of Bioassay Methods of Bioassay for Agonists Bioassay of Antagonists Bioassay of some grievous medicates period status of Bioassay in different Pharmacopoeia other formal Bioassays Keywords Bioassay, official method, adrenaline, digitalis, d-tubocurarine, heparin, insulin, oxytocin, gonadotropin, chorionic gonadotropin, urokinase, streptokinase,diphtheria vaccine, plague vaccine 1 Bioassay is defined as the estimation of the potency of an lively ruler in a unit quantity of homework or detection and step of the concentration of the substance in a preparation employ biological methods (i.e. observation of pharmacological effects on animate tissues, microorganisms or immune cells or animal). Hence micro assay, radioimmunoassay argon also regarded as ` bioassay. tardily `biote chnology has also been considered for bioassay. Bioassay of the products wish well erythropoietin, hepatitisB vaccine and so forth is being done through biotechnology. Importance of Bioassay Bioassays, as compared to other methods of assays (e.g.

chemical or tangible assay) are little accurate, less elaborate, more laborious, more troublesome and more expensive. However, bioassay is the only method of assay if (1) active voice principle of medicine is unknown or can non be isolated, e.g. insulin, rump pituitary extract etc. (2) Chemical method is both not available or if available, it is too complex and unres ponsive or requires higher dose e.g. insulin! , acetylcholine. (3) Chemical composition is not known, e.g. long acting thyroid stimulants. (4) Chemical composition of drug differs but have the same pharmacological action and vice-versa, e.g. cardiac glycosides, catecholamines etc. Moreover, even if chemical methods are available and the results of bioassay conflict with those of the chemical assay,...If you want to get a considerable essay, order it on our website: BestEssayCheap.com

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